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Hepatit

Viral hepatitis is a global health problem that affects hundreds of millions of people. According to the World Health Organization, 2 billion people have been infected with hepatitis B (HBV) and more than 360 million have a chronic HBV infection. In addition, 170 million people have chronic hepatitis C (HCV); about 3 – 4 million new HCV infections occur every year and about 80% of newly infected patients develop chronic HCV.1,2

 

Hepatitis B

The clinical consequences of HBV and HCV infection can be serious and include cirrhosis and liver cancer. Furthermore, the diagnosis, staging, and monitoring of hepatitis is complicated, making diagnostic testing an important element in the management of patients with hepatitis. Diagnostic tests are essential for:

  • Identifying patients with HBV or HCV infection, because many infected individuals are asymptomatic
  • Determining whether an individual has an acute or chronic infection
  • Establishing the viral genotype to help determine therapy
  • Monitoring a patient’s viral load to assess their disease status and response to therapy
  • Detecting fibrosis and measuring its degree

 

Hepatitis B
  • Blood tests of liver function help to determine the extent of liver damage
  • Testing with immunoassays helps to diagnose viral hepatitis and whether the infection is acute or chronic
  • Nucleic acid testing (NAT) helps to confirm diagnosis, guide treatment, and indicate prognosis
  • Biomarkers, imaging, and biopsy help to stage the degree of fibrosis and liver injury
  • Viral load testing is used to monitor therapy and indicate response

 

The pocket guide Diagnostic Testing in the Management of Viral Hepatitis B and Hepatitis C, developed by Siemens Healthcare Diagnostics, helps clarify the role of these tests aiding clinicians with patient management.

 

The guide discusses:

  • Hepatitis B and C Infection Worldwide
  • Evaluating Liver Function Using Routine Laboratory Tests
  • HBV and HCV Histology Testing Determines Degree of Fibrosis and Cirrhosis
  • Hepatitis B Virus (HBV) Testing Identifies Those with Acute or Chronic HBV
  • HBV Patient Classification Based on LFTs, Molecular Testing and Histology
  • HBV Molecular DNA Testing Helps Monitor and Stage Chronic HBV
  • Hepatitis C Testing
  • HCV Molecular (RNA) Testing Is Key in Optimizing Therapy
  • An outlook on the future of virology and hepatology

 

Access the Clinician’s Reference Guide “Diagnostic Testing in the Management of Viral Hepatitis B and Hepatitis C”447kB


Siemens offers diagnostic testing products for screening, diagnosis and monitoring of Hepatitis, as well as for liver function testing. Product availability varies by region. Contact your local Sales Representative for a copy of the Siemens Hepatitis Product Portfolio Guide appropriate for your country.
 

References:
1. World Health Organization. Hepatitis C. Fact Sheet No 164. http://www.who.int/wer. Accessed October 6, 2008.
2. Centers for Disease Control Division of Viral Hepatitis. FAQs for Health Professionals. http://www.cdc.gov/hepatitis/HCV/HCVfaq.htm. Accessed October 6, 2008.
 

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